|
KMID : 0613820080180020249
|
|
Journal of Life Science
2008 Volume.18 No. 2 p.249 ~ p.254
|
|
|
The Effect of Sea Tangle Extract on Serum Lipid Level in Ovariectomized Rats
|
|
Lee Young-Ae
Kim Mi-Hyang
|
|
|
Abstract
|
|
|
|
This study was performed to investigate the effects of sea tangle (ST) extracts on serum lipid concentration in ovariectomized rats. Weight-matched female Sprague-Dawley strain rats were assigned to four groups. Three groups were surgically ovariectomized (OVX). The fourth group was sham operated. Rats were randomly assigned to the following groups: sham-operated rats (Sham), ovariectomized control rats (OVX-control), ovariectomized rats supplemented with ST at 50 mg/kg body wt (OVX-ST50) and ovariectomized rats supplemented with ST at 200 mg/kg body wt (OVX-ST200). The activities of serum GOT and GPT were increased by ovariectomized. The serum GOT levels in OVX-ST50 and OVX-ST200 groups were decreased than OVX-control group. But GPT level was only decreased in the serum of OVX-ST200 group. Serum total cholesterol and triglyceride contents decreased in sham group compared with OVX-control group by ovariectomy. Six weeks feeding of ST extract resulted in a significant lowering of serum triglyceride and lowering tendency of total cholesterol Level. The serum HDL-cholesterol was higher in ST groups than OVX-control group. These results suggest that the beneficial effect of ST extract may be used to possibly improve on the lipid metabolic syndrome of menopausal women.
|
|
|
KEYWORD
|
|
|
Sea tangle, ovariectomized rat, lipid metabolism, postmenopausal
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|